Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis

Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis.

Hypoxia and Hypoxia-Inducible Factors in Leukemias

Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor. The marrow microenvironment contributes considerably in supporting the protection and developmen...

Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-inducible Factors

Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois; and Vascular Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry; and McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medi...

Rheumatoid arthritis, cytokines and hypoxia

R arthritis (RA) is a chronic recurrent, systemic inflammatory disease primarily involving the synovial membranes of multiple joints, followed by cartilage and bone destruction, which eventually leads to joint deformities and loss of articular functions.1 The clinical course of the disorder is extremely variable, ranging from mild, selflimiting arthritis to rapidly progressive multi-system infl...

SnapShot: Hypoxia-Inducible Factors

Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and the ER stress response. This SnapShot will ...